COMUNICADO: Atrial Fibrillation Found to be Common in Patients With Atherothrombosis, Increases Risk of Cardiovascular Death, Heart

Actualizado 07/11/2008 18:01:36 CET


- CV death 129% greater (3.2% vs 1.4%; p<0.0001)
- All-cause death 87% greater (4.3 vs 2.3, p<0.0001)
- Non-fatal stroke 50% greater (2.4% vs 1.6%, p<0.0001)
- The combined endpoint of CV death/heart attack/stroke and/or
hospitalization for atherothrombotic event 48% greater (17.9% vs
12.1%, respectively; p<0.0001), and highest in patients initially
recruited
with PAD (27.1%)

Only 58.4% of AF patients received antiplatelet agents, and only 53.1% received anticoagulant therapy. The rate of bleeding requiring hospitalization was higher in AF vs non-AF patients, respectively: 1.5% vs 0.8% (p<0.0001); the investigators speculated that this may have been due to the more frequent use of anticoagulants (53.1% vs 7.1%).

References

1. Goto S, Bhatt DL, Rother J, Alberts M, Hill MD, Ikeda Y, et al. Prevalence, clinical profile, and cardiovascular outcomes of atrial fibrillation patients with atherothrombosis. Am Heart J 2008;156:855-863.

2. Bhatt DL, Steg PG, Ohman EM, Hirsch AT, Ikeda Y, Mas JL, et al. International prevalence, recognition, and treatment of cardiovascular risk factors in outpatients with atherothrombosis. JAMA 2006;295(2):180-189.

3. Ohman EM, Bhatt DL, Steg PG, Goto S, Hirsch AT, Liau CS, et al. The REduction of Atherothrombosis for Continued Health (REACH) Registry: an international, prospective, observational investigation in subjects at risk for atherothrombotic events-study design. Am Heart J 2006;151(4):786 e1-10.

4. Steg PG, Bhatt DL, Wilson PWF, D'Agostino R, Ohman EM, Rother J, et al. One-year cardiovascular event rates in outpatients with atherothrombosis. JAMA. 2007;297:1197-1206.

5. Feinberg WM, Blackshear JL, Laupacis A, Kronmal R, Hart RG. Prevalence, age distribution, and gender of patients with atrial fibrillation. Analysis and implications. Arch Intern Med 1995;155(5):469-73.

For Further Information, please contact: Nick James, Chandler Chicco Agency, 7 Nov. (0) - 7776-258-990, n.james@cca-uk.com; Dr. Deepak Bhatt, On Behalf of the REACH STEERING COMMITTEE, +1-857-203-6840/6841; Dr. Shinya Goto, Tokai University, +81-463-58-1211

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