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i. Hussain, Maha, et al. Enzalutamide in Men with Nonmetastatic Castration-Resistant Prostate Cancer. N Engl J Med 2018; 378:2465-74
ii. European Medicines Authority. Summary of Product Characteristics: Xtandi 40 mg soft capsules. Accessed 22-06-18 http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_...
iii. Torre L. et al. Global Cancer Incidence and Mortality Rates and Trends - an Update. Cancer Epidemiol Biomarkers Prev; 25(1):pp16-27 January 2016
iv. European Commission. Epidemiology of prostate cancer in Europe (03-17-2017). https://ec.europa.eu/jrc/en/publication/epidemiology-prostat... . Accessed 22-06-2018.
v. American Cancer Society. Key Statistics for Prostate Cancer. https://www.cancer.org/cancer/prostate-cancer/about/key-stat... . Accessed 06-13-2018.
vi. Kirby M, Hirst C, Crawford ED. Characterising the castration-resistant prostate cancer population: a systematic review. Int J Clin Pract 2011;65(11):1180-92.
vii. Luo J, Beer T, Graff J. Treatment of nonmetastatic castration-resistant prostate cancer. Oncology 2016;30(4):336-44.
viii. Smith MR, Kabbinavar F, Saad F, et al. Natural history of rising serum prostate-specific antigen in men with castrate nonmetastatic prostate cancer. J Clin Oncol 2005;23(13):2918-25.
ix. Smith MR et al. Disease and host characteristics as predictors of time to first bone metastasis and death in men with progressive castration-resistant nonmetastatic prostate cancer. Cancer 2011;117: 2077-2085
x. Tran C, et al. Development of a second-generation antiandrogen for treatment of advanced prostate cancer. Science 2009; 324:787-790
xi. Hu R, Denmeade SR and Luo J. Molecular processes leading to aberrant androgen receptor signaling and castration resistance in prostate cancer. Expert Rev Endocrinol Metab 2010; 5 (5): 753-764
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