COPD Landmark Trial UPLIFT Proves Tiotropium Sustains Lung Function Improvements Over Four Years and Improves Survival R

Tiotropium has demonstrated significant and sustained bronchodilation (opening of the airways)(7) and reduction in hyperinflation (air trapping).(8, 9) Tiotropium also demonstrated superior and sustained improvements in lung function (FEV1) over ipratropium bromide (ATROVENT) Inhalation Aerosol, a current first-line therapy for COPD, which were maintained over one year (6) and has also demonstrated superior improvement in key lung function parameters over salmeterol.(10) In addition, in placebo controlled studies, patients treated with tiotropium had less activity induced breathlessness and improved exercise endurance. They required fewer doses of rescue medications, had fewer exacerbations and COPD-related hospitalizations. (7) In clinical trials, the most common adverse reaction reported with tiotropium was dry mouth, which was usually mild and often resolved spontaneously during treatment. (7) Long-acting bronchodilators, including tiotropium, are a preferred maintenance therapy for COPD from stage II onwards according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) treatment guidelines. (2)

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Webcast and additional media materials

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References

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(*) Health-related quality of life was evaluated using the Saint George's Respiratory Questionnaire (SGRQ), where a four-point decrease in SGRQ score is considered to be a clinically meaningful improvement in a patient's health-related quality of life.

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(1) Tashkin DP, Celli B, Senn S, et al. A 4-year trial of tiotropium in chronic obstructive pulmonary disease. N Engl J Med 2008; 359: 1543-54.

(2) Global Initiative for Chronic Obstructive Lung Disease. Global Strategy for the Diagnosis, Management and Prevention of Chronic Obstructive Pulmonary Disease: http://www.goldcopd.com/Guidelineitem.as... Updated: 2007

(3) Source: World Health Report. World Health Organization. Available from URL: http://www.who.int/respiratory/copd/en/

(4) World Health Organization. World Health Report 2004. Statistical Annex. Annex table 2 and 3: 120-131.

(5) Casaburi R, Kukafka D, Cooper CB, et al. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest 2005; 127:809-817.

(6) Vincken W, van Noord JA, Greefhorst APM, et al. Improved health outcomes in patients with COPD during 1 year's treatment with tiotropium. Eur Respir J 2002; 19:209-216.

(7) Casaburi R, Mahler DA, Jones PW, et al. A long-term evaluation of once-daily inhaled tiotropium in chronic obstructive pulmonary disease. Eur Respir J. 2002; 1:217-224.

(8) Celli B, ZuWallack R, Wang S, et al. Improvement in resting inspiratory capacity and hyperinflation with tiotropium in COPD patients with increased static lung volumes. Chest 2003; 124: 1743-1748.

(9) O'Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J. 2004 23(6):832-48

(10) Brusasco V, Hodder R, Miravitlles M, et al. Health outcomes following treatment for six months with once daily tiotropium compared with twice daily salmeterol in patients with COPD. Thorax 2003; 58: 399-404.

    
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Contact: Boehringer Ingelheim GmbH, External Communications, Ute E Schmidt, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany, Tel.: +49-6132-779-7296; Head External Communications, Judith von Gordon, Binger Strasse 173, 55216 Ingelheim am Rhein, Germany, Tel.: +49-6132-773-582, E: press@boehringer-ingelheim.com; Pfizer Inc., Director European Communications, Oliver Stohlmann, Tel: +43-152-115-337, E: oliver.stohlmann@pfizer.com; Investor Relations, Jennifer Davis, Tel: +1-212-733-0717, E: jennifer.m.davis@pfizer.com