Lurasidone was launched as Latuda for the treatment of schizophrenia in adults in the United States in February 2011 and in Canada in September 2012 through Sunovion Pharmaceuticals Inc.'s subsidiary Sunovion Pharmaceuticals Canada Inc., in Switzerland in September 2013 through Takeda and in the UK in August 2014 through Sunovion Pharmaceuticals Europe Ltd. In Japan a Phase III clinical study is underway for the treatment of schizophrenia by Sumitomo Dainippon Pharma Co., Ltd.
In March 2011, Sumitomo Dainippon Pharma Co., Ltd. and Takeda Pharmaceutical Company Limited in Japan signed a Development and Commercialization Agreement of the oral formulation of lurasidone hydrochloride for the joint development and exclusive commercialization by Takeda in the 26 member states of the European Union at that time (excluding the United Kingdom), Switzerland, Norway, Turkey and Russia. Sunovion Pharmaceuticals Europe Ltd., a wholly-owned direct subsidiary of Sunovion Pharmaceuticals Inc., is commercializing Latuda in the United Kingdom.
About Schizophrenia
Schizophrenia is a severe, chronic mental illness which can affect both men and women. Patients with schizophrenia have a life span that is decreased by approximately 10-22.5 years compared with the general population,[11],[12] which can in part be due to the undesirable effects of antipsychotics such as weight gain and increased blood sugar.[13]
Antipsychotic pharmacotherapy is the cornerstone of treatment for patients with schizophrenia, with agents generally classed as typical or atypical.[14] Atypical agents are broadly considered to have tolerability benefits over typical agents.[14] Switching antipsychotic medication is common in the treatment of patients with schizophrenia either due to residual or emergent symptoms, adverse events or tolerability issues.[15],[16]
Direct and indirect costs associated with caring for patients with schizophrenia are considerable and can include utilisation of other health services, pharmacotherapy, community care, supportive therapy, informal care and private expenditures, and patient and caregiver lost productivity.[17],[18]Hospitalization associated with patient relapse can significantly increase costs associated with disease management in schizophrenia.[19]
About Takeda Pharmaceuticals International GmbH
Headquartered in Zurich as a subsidiary of Takeda Pharmaceutical Company Limited, Osaka, Japan, the company has a commercial presence covering more than 70 countries, with particular strength in Asia, North America, Europe and fast-growing emerging markets including Latin America, Russia-CIS and China. Areas of focus include cardiovascular and metabolic, oncology, respiratory and immunology, central nervous system, general medicine, and vaccines.
Takeda is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine. Through strategic acquisitions, Takeda has been transforming itself, broadening its therapeutic expertise and geographic outreach.
Additional information about Takeda is available through its corporate website, http://www.takeda.com.
About Sunovion Pharmaceuticals Inc. Sunovion Pharmaceuticals Inc., an indirect, wholly-owned subsidiary of Sumitomo Dainippon Pharma, is headquartered in Marlborough, Mass. Sunovion is a leading pharmaceutical company dedicated to discovering, developing and commercialising therapeutic products that advance the science of medicine and improve the lives of patients and their families. More information about Sunovion Pharmaceuticals Inc. is available at http://www.sunovion.com [http://c/Users/apikalov/AppData/Local/Mi... InternetFiles/koneill/Downloads/www.sunovion.com ] .
References
1. Newcomer MD et al. Effect of lurasidone or risperidone on metabolic syndrome status in patients with schizophrenia: a post hoc analysis of a long-term study. Poster presented at ECNP, Berlin, 2014
2. Mattingly GW et al. An open-label extension study of lurasidone in patients with schizophrenia previously randomized to lurasidone or risperidone. Poster presented at ECNP, Berlin, 2014
3. Loebel AD et al. Evaluation of daytime sleepiness in patients with schizophrenia treated with atypical antipsychotics. Poster presented at ECNP, Berlin, 2014
4. Schooler NR et al. Efficacy of Lurasidone in the Treatment of Schizophrenia With Prominent Negative Symptoms: A Post-Hoc Analysis of Five Short-Term Trials. Poster presented at ECNP, Berlin, 2014
5. Sacchetti E et al. Maintenance efficacy of lurasidone compared to higher-doses of quetiapine XR in schizophrenia: results from a post-hoc analysis. Poster presented at ECNP, Berlin, 2014
6. Thase ME et al. Lurasidone Treatment For Bipolar I Depression: Effect on Core Depression Symptoms. Poster presented at ECNP, Berlin, 2014
7. Ketter TA et al. Lurasidone in Bipolar I Depression: A 24 Week, Open-label Extension Study. Poster presented at ECNP, Berlin, 2014
8. Werner P et al. In vitro receptor binding profile of lurasidone and other commonly used Antipsychotics. Eur Neuropsychopharmacol 2012;22(Suppl 2):S349
9. Ishibashi T et al. Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity. J Pharmacol Exp Ther 2010;334:171-81
10. Latuda. Summary of Product Characteristics. April 2014.
11. Healy D et al. Mortality in schizophrenia and related psychoses: data from two cohorts, 1875-1924 and 1994-2010BMJ Open 2012;2:e001810
12. Tiihonen J et al. 11-year follow-up of mortality in patients with schizophrenia: a population-based cohort study (FIN11 study). Lancet 2009; 374:620-7
13. De Hert M et al. Metabolic and cardiovascular adverse effects associated with antipsychotic drugs. Nat Rev Endocrinol 2012;8:114-26.
14. Lewis DA and Lieberman JA. Catching Up on Schizophrenia: Review Natural History and Neurobiology. Neuron 2000;28:325-34
15. Faries DE et al. Clinical and economic ramifications of switching antipsychotics in the treatment of schizophrenia. BMC Psych 2009; 9:54
16. Tsutsumi C et al. The evolution of antipsychotic switch and polypharmacy in natural practice - A longitudinal perspective. Schizophr Res 2011; 130:40-6
17. Salize HJ et al. Cost of schizophrenia in six European countries. Schizophr Res 2009; 111(1-3):70-7
18. Mangalore R et al. Cost of schizophrenia in England. J Ment Health Policy Econ 2007; 10(1): 23-41
19. Zeidler J et al. The costs of schizophrenia and predictors of hospitalisation from the statutory health insurance perspective. Health Econ Rev 2012; 2(1):9
Media Contacts
Patrick Gaffey
Corporate Communications
Sunovion Pharmaceuticals Inc.
+1-508-357-7500
patrick.gaffey@sunovion.com
Elissa Johnsen
Director, Product Communications
Takeda Pharmaceuticals
+1-224-554-3185
elissa.johnsen@takeda.com
Date of preparation: October 2014
Job number: EUCAN/LUR/2014-10043
