BRAVE Awards Recipients Announced (y 2)

The Shire BRAVE Awards are presented in the spirit of Shire's BRAVE culture, which fosters an environment that encourages its employees and partners to act with integrity; create innovative solutions that make a difference; act on the needs of others; strive to be better every day; and to exemplify trust and openness through teamwork. Nominations for the 2013 Shire BRAVE Awards are expected to be open on or about March 15, 2013.

Notes to editors

About the Shire BRAVE Awards

The Shire BRAVE Awards is an international program created by Shire to honor the courage and dedication of individual caregivers. For the Shire Brave Awards, a caregiver is defined as an individual who is providing regular, consistent care for another person(s). The caregiver cannot be a professional healthcare provider and cannot be compensated in any formal way through their efforts as a caregiver. The caregiver can be a relative, neighbor, or friend who gives their time, support, and compassion regularly, helping another person(s) who is (partly or wholly) unable to care for themselves due to health issues, injury, or other extenuating circumstance. For further information on the Shire BRAVE Awards, including official rules, legal disclosures, and privacy policy please visit http://www.ShireBRAVEAwards.com.

SHIRE PLC

Shire enables people with life-altering conditions to lead better lives.

Through our deep understanding of patients' needs, we develop and provide healthcare in the areas of:

        
        - Behavioral Health and Gastro Intestinal conditions
        - Rare Diseases
        - Regenerative Medicine

as well as other symptomatic conditions treated by specialist physicians.

We aspire to imagine and lead the future of healthcare, creating value for patients, physicians, policymakers, payors and our shareholders.

For further information on Shire, please visit the Company's website: http://www.shire.com.

        
        For further information please contact:
        Matthew Cabrey mcabrey@shire.com, +1-484-595-8248
        Beverly Volpe bvolpe@simonpr.com, +1-215-545-4715 x24
        Jessica Mann jmann@shire.com, +44-1256-894-280