Multaq(R) First-line Option in New 2010 ESC Guidelines for the Management of Atrial Fibrillation (y 2)

In the U.S., Multaq(R) is indicated to reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent atrial fibrillation (AF) or atrial flutter (AFL), with a recent episode of AF/AFL and associated cardiovascular risk factors (i.e., age >70, hypertension, diabetes, prior cerebrovascular accident, left atrial diameter is greater than or equal to 50 mm or left ventricular ejection fraction [LVEF] <40%), who are in sinus rhythm or who will be cardioverted.(15) Multaq(R) is contraindicated in patients with NYHA Class IV heart failure, or NYHA Class II-III heart failure with a recent decompensation requiring hospitalization or referral to a specialized heart failure clinic.

Multaq(R) is currently available in 20 countries including the U.S., Canada, Switzerland, Mexico, Taiwan, South Korea, Germany, Denmark, Ireland, Norway, Finland, Austria, Cyprus, Malta, Estonia, Sweden, Israel, Peru, Mexico, Hong Kong the UK and is being launched in most European countries in 2010.

For more information about AF and Multaq(R): http://www.dronedarone-atrial-fibrillation-pressoffice.com

About sanofi-aventis

Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and distributes therapeutic solutions to improve the lives of everyone. Sanofi-aventis is listed in Paris (EURONEXT: SAN) and in New York (NYSE: SNY). For more information, please visit: http://www.sanofi-aventis.com.

Forward-Looking Statements

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1. The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology. European Heart Journal 2010. doi: 10.1093/eurheartj/ehq278. Guidelines for the management of atrial fibrillation. http://eurheartj.oxfordjournals.org/

2. National Services Framework for Coronary Heart Disease. Chapter Eight: Arrhythmia and Sudden Cardiac Death. March 2005

3. Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 2001; 285:2370-5.

4. Lloyd-Jones et al. Lifetime Risk for Development of Atrial Fibrillation: The Framingham Heart Study. Circulation. 2004; 110:1042-1046.

5. Fuster V et al. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation. European Heart Journal (2006) 27, 1979-2030.

6. Benjamin EJ, Wolf PA, D'Agostino RB, Silbershatz H, Kannel WB, Levy D. Impact of atrial fibrillation on the risk of death: the Framingham Heart Study. Circulation 1998 Sep 8; 98(10):946-52.

7. Ringborg et all, Europace 2008 10; 400-411

8. Wattigney WA et al. Circulation 2003;108:711-6

9. Le Heuzey JY et al. Am Heart J 2004;147:121-6

10. Coyne KS et al. Value Health 2006;9:348-56

11. Stewart S et al. Heart 2004;90:286-92

12. Reynolds MR et al. J Cardiovasc Electrophysiol 2007;18:628-33

13. McBride D et al. Value Health 2008;12:293-301

14. European Medicines Agency. European Public Assessment Report. Doc. Ref.: EMA/625172/2009; EMEA/H/C/1043 http://www.ema.europa.eu/ema/index.jsp?c.... Last accessed 28 July.

15. MULTAQ U.S. Prescribing information http://products.sanofi-aventis.us/Multaq/Multaq.pdf. Last accessed 28 July.

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Media Contact: Ingrid Görg-Armbrecht, +33-1-53-77-46-25 or +33-6-38-10-50-87, ingrid.goerg-armbrecht@sanofi-aventis.com