Record Number of Bendamustine Abstracts Accepted for Presentation at the Annual Meeting of the American Society of Hemat

SymBio Pharmaceuticals Ltd holds exclusive rights to develop and market bendamustine HCL in Japan (sublicensed to Eisai Co Ltd) and selected Asian countries including Hong Kong and Singapore. In South America and Australasia the commercial rights are held by Janssen-Cilag Ltd.

CHOP-R/CVP-R Treatment Regimens

Rituximab plus chemotherapy, most commonly CHOP or CVP, is the current first-line standard of care for patients with advanced iNHL, and patients with mantle cell lymphoma who are not fit for high-dose chemotherapy.[9]

CHOP, a multi-drug chemotherapy regimen, is a combination of three chemotherapy injections/infusions (cyclophosphamide, doxorubicin and vincristine) on a single day, with a fourth agent (prednisone) taken orally for five days. Each cycle is repeated every three weeks for 6-8 cycles.

CVP treatment follows a similar regimen but comprises two chemotherapy injections/infusions (cyclophosphamide and vincristine), followed by a five-day course of prednisone tablets.

References

1. Flinn IW, Van der Jagt RH, Kahl BS, et al. An Open-Label, Randomized Study of Bendamustine and Rituximab (BR) Compared with Rituximab, Cyclophosphamide, Vincristine, and Prednisone (R-CVP) or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in First-Line Treatment of Patients with Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL): The Bright Study. Abstract presented at ASH 2012. Available at https://ash.confex.com/ash/2012/webprogr....

2. Rummel MJ, Niederle N, Maschmeyer G, et al. Subanalysis of the StiL NHL 1-2003 Study: Achievement of Complete Response with Bendamustine-Rituximab (B-R) and CHOP-R in the First-Line Treatment of Indolent and Mantle Cell Lymphomas Results in Superior Survival Compared to Partial Response. Abstract presented at ASH 2012. Available at https://ash.confex.com/ash/2012/webprogr....

3. Burke JM, Van der Jagt RH, Kahl BS, et al. Differences in Quality of Life Between Bendamustine Plus Rituximab Compared with Standard First-Line Treatments in Patients with Previously Untreated Advanced Indolent Non-Hodgkin's Lymphoma or Mantle Cell Lymphoma. Abstract presented at ASH 2012. Available at https://ash.confex.com/ash/2012/webprogr....

4. Rummel MJ, Lerchenmüller C, Greil R, et al. Bendamustin-Rituximab Induction Followed by Observation or Rituximab Maintenance for Newly Diagnosed Patients with Waldenström's Macroglobulinemia: Results From a Prospective, Randomized, Multicenter Study (StiL NHL 7-2008 -MAINTAIN-; ClinicalTrials.gov Identifier: NCT00877214). Abstract presented at ASH 2012. Available at https://ash.confex.com/ash/2012/webprogr....

5. Ulrich Knauf W, Abenhardt W, Nusch A, Grugel R, Marschner N. Bendamustine-Rituximab (BR) Replaces R-CHOP As "Standard of Care" in the Treatment of Indolent Non-Hodgkin Lymphoma in German Hematology Outpatient Centres. Abstract presented at ASH 2012. Available at https://ash.confex.com/ash/2012/webprogr....

6. Non-Hodgkin lymphoma incidence statistics: In the EU and worldwide. Cancer Research UK. Available at http://www.cancerresearchuk.org/cancer-info/cancerstats/type... [http://www.cancerresearchuk.org/cancer-info/cancerstats/type...]. Accessed November 2012. European Age-Standardised rates calculated by the Cancer Research UK Statistical Information Team, 2011, using data from GLOBOCAN 2008 v1.2, IARC, version 1.2 [http://globocan.iarc.fr].

7. Gascoyne, Randy D. Hematopathology approaches to diagnosis and prognosis of indolent B-cell lymphomas. ASH Education Program Book 2005.1 (2005): 299-306.

8. European Age-Standardised rates calculated by the Cancer Research UK Statistical Information Team, 2011, using data from GLOBOCAN 2008 v1.2, IARC, version 1.2 [http://globocan.iarc.fr]. Available at Non-Hodgkin lymphoma incidence statistics: In the EU and worldwide. Cancer Research UK http://www.cancerresearchuk.org/cancer-info/cancerstats/type... [http://www.cancerresearchuk.org/cancer-info/cancerstats/type...]. Accessed November 2012.

9. Gribben JG; How I treat indolent lymphoma. Blood 2007;109:4617-4626.

CONTACT: For further information please contact: Bily Kuo,bily.kuo@mundipharma.co.uk, +44(0)1223-397-118, Julie Masters,julie.masters@fleishmaneurope.com, +44(0)2073-957-129.