References
[1] De Bodinat C, et al. Agomelatine, the first melatonergic
antidepressant: discovery, characterization and development. Nature
Reviews. Drug Discovery 2010; 9:628-642
[i] Leproult R, Van Ondergergen A, L'Hermite-Balériaux M et
al.Phase-shifts of 24-h hormonal release and body temperature following
early evening administration of the melatonin agonist agomelatine in
healthy older men. Clin. Endocrinol. 2005;63:298-304
[ii] Hale A, Corral R, Mencacci O, Saiz Ruiz J, Severo A, Gentil V.
Superior efficacy of agomelatine vs fluoxetine in severe MDD patients: a
randomised, double-blind study. J. Eur. College of Neuropsychopharmacol.
2009;19(suppl 3):S418
[iii] Leproult R, Van Ondergergen A, L'Hermite-Balériaux M, Van Cautert
E, Copinschi G. Clin. Endocrinol. 2005;63:298-304
[iv] Hale A, Corral R, Mencacci O, Saiz Ruiz J, Severo A, Gentil V.
Superior efficacy of agomelatine vs fluoxetine in severe MDD patients: a
randomised, double-blind study. J. Eur. College of Neuropsychopharmacol.
2009;19(suppl 3):S418
[v] De Bodinat C, et al. Agomelatine , the first melatonergic
antidepressant : discovery, characterization and development. Nature
Reviews. Drug Discovery 2010; 9:628-642
[vi] Goodwin G et al, Agomelatine Prevents Relapse in Patients with Major
Depressive Disorder Without Evidence of a Discontinuation Syndrome: A
24-Week Randomized, Double-Blind, Placebo-Controlled Trial. J. Clin.
Psychiatry. 2009;70(8):1128-1137
[vii] Stahl SM, Fava M, Trivedi MH, Caputo A, Shah A, Post A. Agomelatine
in the Treatment of Major Depressive Disorder: An 8-Week, Multicenter,
Randomized, Placebo-Controlled Trial J. Clin. Psychiatry.
2010;71(5):616-626
[viii] Kasper S et al. Efficacy of the Novel Antidepressant Agomelatine
on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms
in Patients with Major Depressive Disorder: A Randomized, Double-Blind
Comparison with Sertraline. J. Clin. Psychiatry. 2010;71(2):109-120
[ix] Kennedy S, Rizvi S. Agomelatine in the treatment of major depressive
disorder: potential for clinical effectiveness. CNS Drugs 2010 Review
Article
[x] Kennedy SH, Rizvi S, Fulton K, Rasmussen J. A Double-Blind Comparison
of Sexual Functioning, Antidepressant Efficacy, and Tolerability Between
Agomelatine and Venlafaxine XR. J Clin Psychopharmacol. 2008;28:329-333
[xi] Montgomery SA, Kennedy SH, Burrows GD, Lejoyeux M, Hindmarch I.
Absence of discontinuation symptoms with agomelatine and occurrence of
discontinuation symptoms with paroxetine: a randomized, double-blind,
placebo-controlled discontinuation study. Int Clin Psychopharmacol.
2004;19:271-280
[xii] Valdoxan(R) Summary of Product Characteristics
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