Two essential steps in the HIV life cycle are replication - when the virus turns its RNA copy into DNA - and integration - the moment when viral DNA becomes part of the host cell's DNA. These processes require two enzymes called reverse transcriptase and integrase. NRTIs and INSTIs interfere with the action of the two enzymes to prevent the virus from replicating. This decrease in replication will lead to less virus being available to cause subsequent infection of uninfected cells.
Please refer to the full US Prescribing Information for contraindications, special warnings and precautions for use. [7]
Triumeq is a registered trademark of the ViiV Healthcare group of companies.
About ViiV Healthcare
ViiV Healthcare is a global specialist HIV company established in November 2009 by GlaxoSmithKline and Pfizer dedicated to delivering advances in treatment and care for people living with HIV. Shionogi joined in October 2012. The company's aim is to take a deeper and broader interest in HIV/AIDS than any company has done before and take a new approach to deliver effective and new HIV medicines, as well as support communities affected by HIV. For more information on the company, its management, portfolio, pipeline, and commitment, please visit http://www.viivhealthcare.com
References
1. Trottier B, Lake J, Logue K et al. Switching to Abacavir/Dolutegravir/Lamivudine combination (ABC/DTG/3TC FDC) from a PI, INI or NNRTI based regimen maintains HIV suppression. Presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), 17-21 September 2015, San Diego, California
2. Raffi F, Jaeger H, Quiros-Roldan E, Albrecht H, Belonosova E, Gatell JM, Baril J-G, Domingo P, Brennan C, Almond S, Min S, for the SPRING-2 Study Group. Once-daily dolutegravir versus twice-daily raltegravir in antiretroviral-naive adults with HIV-1 infection (SPRING-2 study): 96 week results from a randomised, double-blind, non-inferiority trial. Lancet Infect Dis. 2013;13(11):927-935.
3. Pappa K, Baumgarten A, Felizarta F, et al. Dolutegravir (DTG) + abacavir/lamivudine once daily superior to tenofovir/emtricitabine/efavirenz in treatment naive HIV subjects: 144-week results from SINGLE (ING114467). Abstract presented at: 54th Interscience Conference on Antimicrobial Agents and Chemotherapy; September 5-9, 2014; Washington, DC, USA.
4. Castagna S, et al. Dolutegravir in antiretroviral-experienced patients with raltegravir- and/or elvitegravir-resistant HIV-1: 24-week results of the Phase III VIKING-3 study. J Infect Dis 2014;210:354-62
5. Vavro C, Huang J, Avatapally C, Min S, Ait-Khaled M. Durable efficacy and limited integrase resistance in subjects receiving dolutegravir after failing a prior regimen: week 48 results from VIKING-3. Rev Antiviral Ther Infect Dis. 2014;2:Abstract O-10.
6. Molina J, et al. Once-daily dolutegravir versus darunavir plus ritonavir for treatment-naive adults with HIV-1 infection (FLAMINGO): 96 week results from a randomised, open-label, phase 3b study. Lancet HIV 2015. Published online March 2015 http://dx.doi.org/10.1016/S2352-3018(15)00027-2 (Last Accessed March 2015)
7. Triumeq US label
Cautionary statement regarding forward-looking statements: GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described under Item 3.D 'Risk factors' in the company's Annual Report on Form 20-F for 2014.
CONTACT: Contact:Patricia O'Connor, +44-7469-375019, Global Communications, ViiV HealthcareMarc Meachem, +1-919-483-8756, US Communications;GSK enquiries:UK Media enquiries:Simon Steel, +44(0)20-8047-5502 (London)David Daley, +44(0)20-8047-5502 (London)US Media enquiries:Sarah Alspach, +1-202-715-1048 (Washington, DC)Sarah Spencer, +1-215-751-3335 (Philadelphia)Analyst/Investor enquiries:Ziba Shamsi, +44(0)20-8047-5543 (London)Tom Curry, +1-215-751-5419 (Philadelphia)Gary Davies, +44(0)20-8047-5503 (London)James Dodwell, +44(0)20-8047-2406 (London)Jeff McLaughlin, +1-215-751-7002 (Philadelphia)
