BASEL, Switzerland, May 16 /PRNewswire/ -- Patients with breast or colorectal cancer, two of the world's most common cancers, can expect further treatment advances with Avastin(R) (bevacizumab) and Herceptin(R) (trastuzumab) following new data that is being presented at the 44th American Society of Clinical Oncology (ASCO) annual meeting in Chicago at the end of May. Around 30,000 medical experts will attend the meeting which is the premier event for cancer therapy worldwide.
The Roche data will show that Avastin and Herceptin are continuing to offer further hope of improving survival in patients with cancers that are still devastating thousands of lives each year.
Breast cancer
- Avastin: Late-breaking Phase III data from the AVADO study
investigating Avastin in combination with docetaxel (docetaxel, also
known as Taxotere, is one of the most commonly used chemotherapies for
breast cancer) will highlight the encouraging efficacy and safety results
in patients treated first-line for locally recurrent or metastatic HER-2
negative breast cancer.
- Herceptin: New results using Herceptin-based therapy for patients with
aggressive HER-2 positive breast cancer will also be unveiled. The GBG26
study data will focus on the importance of continued treatment with
Herceptin in women with advanced metastatic breast cancer whose disease
progressed on a Herceptin-based therapy.
- Pertuzumab: Very promising phase II data will be presented on the
investigational drug pertuzumab which will highlight the benefits that
pertuzumab in combination with Herceptin could offer to patients with
advanced breast cancer. Pertuzumab is the first of a new, innovative
class of targeted agents known as HER dimerisation inhibitors that can
inhibit cancer cell growth and ultimately lead to death of cancer cells
Colorectal cancer
- Avastin: The first presentation of data from Avastin-based
therapy with or without cetuximab (a drug which attacks cancer
differently to Avastin) in patients with metastatic colorectal cancer
will be shared.
- Avastin: Impressive long-term overall survival data at two
years, involving some 4,000 patients treated with Avastin first-line in
combination with a variety of chemotherapy regimens will confirm the
pivotal role that Avastin is now playing in patients with advanced
colorectal cancer. The results of the studies are significant because
over 50 percent of people diagnosed with colorectal cancer currently die
of the disease and these data show that improvements in survival are
achievable. (1)
Roche will present nearly 300 abstracts and posters at ASCO that demonstrate advances in other major cancers, as well as the data already described above in breast and colorectal. With one of the most comprehensive oncology research and development pipelines in the industry, Roche is striving to deliver even more treatment options in the fight against cancer. For example, Avastin's clinical trial program includes 40,000 patients worldwide.
Key sessions at which Roche data will be presented include:
Breast cancer
Avastin AVADO study. Miles D, et al, Sunday I June 2008,
Abstract No. LBA1011, oral 8:30am - 8:45am, E
presentation Hall D1
ASCO press briefing Saturday 31 May
2008, 9.00am, Press
Centre
Herceptin HER2-positive metastatic breast Tuesday 3 June 2008,
cancer study. Minckwitz G Von, et 8:00am - 12:00pm,
al, Abstract No. 1025, Poster No. 6. E450b
pertuzumab Results of a phase II trial of Tuesday 3 June 2008,
trastuzumab and pertuzumab in 8:00am - 12:00pm,
patients with HER2-positive E450b
metastatic breast cancer (MBC) who
had progressed during trastuzumab
therapy. Gelmon K et al, Abstract
No. 1026, Poster No. 7.
Colorectal cancer
Avastin Initial Safety Report of National Saturday 31 May
Surgical Adjuvant Breast and Bowel 2008, 3:10 p.m. E
Project (NSABP) C-08, a Randomized Hall D1
Phase III Study of Modified
5-Fluorouracil (5-FU)/Leucovorin and
Oxaliplatin (mFOLFOX6) With or
Without Bevacizumab in the Adjuvant
Treatment of Patients With Stage
II/III Colon Cancer
Avastin Randomized phase III study of Saturday 31 May
capecitabine, oxaliplatin, and 2008, 4.45pm -
bevacizumab with or without 5.00pm, E Hall D1
cetuximab in advanced colorectal
cancer (ACC), the CAIRO2 study of
the Dutch Colorectal Cancer Group
(DCCG). Punt C, et al, Abstract No.
LBA4011
Avastin Surgery with curative intent in Sunday 1 June 2008,
patients treated with first-line 8:00am - 12:00pm,
chemotherapy + bevacizumab for E450a
metastatic colorectal cancer: First
BEAT and NO16966 Cassidy J, et al,
Abstract No. 4022, Poster No. 9
Avastin Final efficacy results for Sunday 1 June 2008,
bevacizumab plus standard first-line 8:00am - 12:00pm,
chemotherapies in patients with E450a
metastatic colorectal cancer: First
BEAT
Berry S, et al, Abstract No. 4025,
Poster No. 12.
Avastin The safety of long-term bevacizumab Monday 2 June 2008,
use: Results from the BRiTE 8.00am - 12.00pm, S
observational cohort study (OCS). Hall A1
Purdie D, et al, Abstract No. 4103,
Poster No. 14G
Avastin Safety and effectiveness of Sunday 1 June 2008,
bevacizumab (BV) and chemotherapy 8.00am - 12.00pm,
(CT) in elderly patients (pts) with E450a
metastatic colorectal cancer (mCRC):
Results from the BRiTE observational
cohort study. Kozloff M, et al,
Abstract N0. 4026, Poster No. 13
Full details of key Roche data presentations will be available on Friday 30th May at an invitation-only media event for non-US journalists. All abstracts are available at: http://www.asco.org/ASCO/Meetings.
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