Boehringer Ingelheim's pramipexole (Sifrol(R)/Mirapexin(R)) Can Provide Benefit of Improved Mood Disturbance for People

Pramipexole may cause patients to fall asleep without any warning, even while doing normal daily activities such as driving. When taking pramipexole hallucinations may occur and sometimes patients may feel dizzy, sweaty or nauseated upon standing up. It should be noted that impulse control disorders/compulsive behaviours may occur while taking medicines to treat Parkinson's disease, including pramipexole.

Boehringer Ingelheim

The Boehringer Ingelheim group is one of the world's 20 leading pharmaceutical companies. Headquartered in Ingelheim, Germany, it operates globally with 143 affiliates in 47 countries and almost 37,500 employees. Since it was founded in 1885, the family-owned company has been committed to researching, developing, manufacturing and marketing novel products of high therapeutic value for human and veterinary medicine.

In 2005, Boehringer Ingelheim posted net sales of 9.5 billion euro while spending almost one fifth of net sales in its largest business segment Prescription Medicines on research and development.

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References

(1). Trenkwalder C. et al. Sustained effects of pramipexole on mood in patients with Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P1156. To be presented 3 September 2006.

(2). Leissner L et al. Effect of pramipexole on mood in patients with Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P1186. To be presented 3 September 2006.

(3). Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, et al. Restless Legs Syndrome prevalence and impact: REST general population study. Arch Intern Med 2005; 165: 1286-1292.

(4). Oertel WH et al. Daytime symptoms of Restless Legs Syndrome during pramipexole therapy. EFNS 2006; Glasgow, UK. Poster presentation P1147. To be presented 3 September 2006.

(5). Partinen M et al. Effects of pramipexole on polysomnographic measures of Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P2129. To be presented 4 September 2006.

(6). Trenkwalder C et al. Sustained effects of individually optimised open-label pramipexole on sleep quality in Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P2146. To be presented 4 September 2006.

(7). Stiasny-Kolster K et al. Incremental responder rates to flexibly up-titrated pramipexole in Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P2185. To be presented 4 September 2006.

(8). Oertel WH et al. Safety of pramipexole during 52-week treatment of Restless Legs Syndrome. EFNS 2006; Glasgow, UK. Poster presentation P1191. To be presented 3 September 2006.

(9). Phillips B et al. Epidemiology of restless legs symptoms in adults. Arch Intern Med 2000; 160(14): 2137-2141.

CONTACT: Ursula Bardon, Corporate Division Communications, Boehringer Ingelheim GmbH, 55216 Ingelheim/Germany, Phone: +49-6132-77-2622, Fax: +49-6132-72-2622